GRADUATE SCHOOL OF HEALTH SCIENCES

DEPARTMENT OF MEDICAL BIOCHEMISTRY  

PROFESSORS

TOKULLUGİL, H. Asuman, (Chairperson): M.D. Hacettepe University, School of Medicine.

Specilization Uludağ University, School of Medicine

ÖZALP, Ülkü: B.S. Ankara University, Faculty of Science, Chemistry Engineering Dept. M.S. Birmingham Tech. Univ. ( UK), Ph.D. Birmingham Tech. Univ. ( UK)

GÜR, Esma: M.D. İstanbul University, School of Medicine Specialization İstanbul University, School of Medicine

ASSOCIATE PROFESSORS

DİRİCAN, Melahat: M.D.Uludağ University, School of Medicine. Specialization Uludağ University, School of Medicine

ULUKAYA, Engin: M.D. İstanbul University, Cerrahpasa Medical School. Specialization Uludağ University, School of Medicine Ph.D. School of Biochem and Mol. Biology, Leeds (UK)

ÖZARDA İLÇÖL, Yeşim: M.D. İstanbul University, İstanbul Medical School Specialization Marmara University, School of Medicine

ASSISTANT PROFESSORS

SERDAR, Zehra: M.D. İstanbul University, Cerrahpasa Medical School Specialization Uludağ Üniversity. School of Medicine

SARANDÖL, Emre: M.D. Uludağ University, School of Medicine Specialization Uludağ University, School of Medicine

 

INSTRUCTORS

 

CANGÜL, Hakan: M.D. Uludağ University, School of Medicine Ph.D. Uludağ University, School of Medicine Ph.D NYU School of Medicine (USA)

ŞAFAK, Özlem: M.D. Uludağ University, School of Medicine Specialization Uludağ University, School of Medicine

ÇOLAKOĞULLARI, Mukaddes: M.D. Ege University, School of Medicine Specialization Uludağ University, School of Medicine

 

GENERAL INFORMATION

 

Biochemistry Department offers doctoral education as a graduate program. Students successfully completing the courses get Ph.D. degree in Biochemistry. During the courses, in addition to learning basics of biochemistry, students should follow the new trends in biochemistry, should be aware of the new literature, should plan scientific projects according to their interests and participate in research going on in the department. Students also present an article and a seminar each semester, during which they gain the knowledge and skill on literature search and preparation and presentation of a seminar. 

 

We aim bringing up the students who have PhD education in Biochemistry Department planning projects on oxidative stress and cancer/apoptosis issues which can

 

compete in world standarts and making publications in qualified journals such as Nature and also we intend making our laboratory facility where students prefer having PhD education.

 

RESEARCH INTERESTS AND FACILITIES

 

Scientific research has been concentrated in several main fields in the Department of Biochemistry. Particularly current studies continue on oxidative stress and cancer/apoptosis. The department has the following research laboratories and facilities:

 

1) Research Laboratory: Especially projects on oxidative stress and antioxidant systems are carried out in this laboratory. The principle equipment in this laboratory are spectrophotometer, HPLC system, centrifuges, pHmeter, an incubator, sensitive scale, heater with magnetic mixer, vortex, a water bath, automatic pipettes.

 

2) Students Laboratory:  It is used for students’ education and experiments.

 

3) Apoptosis and Cancer Research Laboratory: Projects on apoptosis and cancer are carried out in this laboratory. The principle equipment in this laboratory is Microplate Reader analytical system.

 

 

GRADUATE PROGRAMS AT THE DEPARTMENT OF MEDICAL BIOCHEMSTRY

GRADUATE CURRICULUM

Ph.D. in Biochemistry

 

GRADUATE COURSES

Professional Must Courses

TBK DZ 01      Structure and Functions of Proteins (2-2)3

TBK DZ 02      Enzyme Reactionsand Enzyme Kinetics (2-2)3

TBK DZ 03      Lipids, Lipoproteins, Apolipoproteins, Lipoprotein Metabolism Disorders (2-2)3

TBK DZ 04      Carbonhidrate Metabolism: Major ve Minor Metabolic Pathways (1-2)2

TBK DZ 05      New Scientific Trends (1-0)0

TBK DZ 06      Literature Research and Transfer (1-0)0

TBK DZ 07      Specific Subjects in PhD (3-0)0

TBK DZ 08      Councelling for PhD (0-1)0

Professional Elective Courses

TBK DS 01     Endocrine System Biochemistry (2-0)2

TBK DS 02     Programmed Cell Death (1-0)1

TBK DS 03     Oksidative Stress and Antioxidants (1-2)1

TBK DS 04     General Laboratory Techniques (0-2)1

TBK DS 05     Basic Analysis Techniques in Biochemistry (0-2)1

   

DESCRIPTION OF THE GRADUATE COURSES

TBK DZ 01 Structure and Functions of  Proteins (2-2)3

Structure, characteristics, reactions and classification of amino acids; endogen synthesis and catabolism pathways of amino acides; Structure of proteins and classification, protein analysis methods are lectured. Experimental applications are done to show amino acid and protein reactions. In these lessons we aim making the graduate to realise the proteins’ characteristics and functions in living organisms.

 

TBK DZ 02 Enzyme Reactions and Enzyme Kinetics (2-2)3

In living organisms, enzymes have very important roles. Also they are very important parameters while evaluating the patients’ clinic situation. Understanding the enzymes structure, working mechanisms and principles are very important in evaluating the enzyme reactions in organism. In this lesson, first we aim to lecture the enzyme structure, principles of enzyme reactions, isoenzymes and their importance, enzyme inhibition and then to study enzyme assays, their importance in clinic diagnosis and follow-up. In this contex, we aim to give lectures on; 1. Structure of enzymes and their characteristics, 2. Principles of enzymatic reactions, 3. Concept of co-factor and working pathways of different co-factors, 4. Enzyme inhibition, 5. Control of enzyme activity in body, 6. Concept of isoenzyme and its’ clinical applications, 7. Enzymes in clinic diagnosis, 8. Enzyme activity assesment techniques.

 

TBK DZ 03 Lipids, Lipoproteins, Apolipoproteins, Lipoprotein Metabolism Disorders (2-2)3

Lipids are energy source of our body, but their excessive levels results with atherosclerosis which causes circulatory system diseases and mortality. Lipoproteins carry the lipids in blood and have roles in lipid metabolism. Aim of this lesson is learning the lipoprotein synthesis, function, catabolism and related disorders. Evaluation of lipid profile and making connection with atherosclerosis is one of our goal. Goals of these lectures are: Teaching the structure and characteristics of lipoproteins, tissues which lipoproteins originated from and alterations in circulation, functions of lipoproteins, ıdentification of lipoprotein metabolism disorders and their mechanisms, concepts of free radical, antioxidant and oxidative stress, risk factors of atherosclerosis , LDL oxidation, paraoxanase enzyme, obesity and metabolic syndrome.

TBK DZ 04 Carbonhidrate Metabolism: Major ve Minor Metabolic Pathways (1-2)2

Structure of carbonhydrates, related metabolic pathways and regulations.

TBK DZ 05 New Scientific Trends (1-0)0

Search, review, presentation and discussion of recent scientific trends about various subjects.

TBK DZ 06 Literature Research and Transfer (1-0)0

Attendance to weekly presentations and discussions of up-to-date literature in the department, review and presentation of recent literature according to special interest, article searchin techniques, presentation of experimental data in a seminar format.

TBK DS 01 Endocrine System Biochemistry (2-0)2

Structure, synthesis, secretion, metabolism functions of hormones and endocrinologic tests and their usage in clinic.

 

TBK DS 02 Programmed Cell Death (1-0)1

Apoptosis is one of the most interesting research subjects in last years and it is thought to have relation in the pathogenesis of many diseases. The goal of this lecture is to discusse the possible role of apopitosis under the pathogenesis of diseases by the help of current knowledge. First of all we will talk about the terminology and accurate defination of apoptosis will be described and also we will make clear the difference between necrosis and apoptosis. Methods used in detecting apoptosis will be mentioned.

TBK DS 03 Oksidative Stress and Antioxidants (1-2)1

a. To study structure, physical and chemical characteristics, cellular sources and reactions of free oxygen radicals  and clinic diseases which they play part in organism.

b.To study the function and structure of antioxidant defense system enzymes (superoxide dismutase, glutathion peroxidase, glutathion reductase, catalase), macromolecules (ceruloplasmine, transferrine, ferritine) and micromolecules (E vitamine, C vitamine, A vitamine, uric acide, bilirubin, oestogen).

TBK DS 04 General Laboratory Techniques (0-2)1

The aim of this lecture is giving instructions about safety rules in laboratory, making solutions, concentration calculations, making dilutions, usage of sensitive scale for weighting chemicals, and pHmetry as well.

TBK DS 05 Basic Analysis Techniques in Biochemistry (0-2)1

The aim of this lecture is making the graduate learning the techniques already used in our laboratory such as photometric and chromatographic devices, elecrophoresis, electrochemical and immunochemical techniques and their principles as well. Also  to bring up the graduate to evaluate the accuracy, linearity, sensitivity of the methods.